[Summary text]
RCT -
Baseline Characteristics N=257
[Theraputic anticoagulation] No. randomised (N):130
Participants with laboratory confirmed COVID-19 (%) 100
Participants with mild illness (%)
Participants with mild or moderate illness (%)
Participants with moderate illness (%)
Participants with moderate to severe illness (%)
Participants with severe illness (%)
Participants with severe or critical illness (%)
Participants with critical illness (%)
Age (mean [range])
Female participants (%)
Paediatric participants (%)
Pregnant participants (%)
Pregnant and/or breastfeeding participants (%)
Frailty index or similar
Participants with hypertension (%)
Participants with diabetes (%)
Participants with chronic heart disease (%)
Participants with cancer (%)
Participants with dementia (%)
Participants with chronic lung disease/COPD (%)
Participants with cognitive impairment (%)
[Prophylactic SOC]No. randomised (N): 127
Participants with laboratory confirmed COVID-19 (%) 100
Participants with mild illness (%)
Participants with mild or moderate illness (%)
Participants with moderate illness (%)
Participants with moderate to severe illness (%)
Participants with severe illness (%)
Participants with severe or critical illness (%)
Participants with critical illness (%)
Age (mean [range])
Female participants (%)
Paediatric participants (%)
Pregnant participants (%)
Pregnant and/or breastfeeding participants (%)
Frailty index or similar
Participants with hypertension (%)
Participants with diabetes (%)
Participants with chronic heart disease (%)
Participants with cancer (%)
Participants with dementia (%)
Participants with chronic lung disease/COPD (%)
Participants with cognitive impairment (%)
Included criteria: [summary of most important criteria]
Hospitalized nonpregnant adults 18 years or older
COVID-19 diagnosed
Supplemental oxygen
Plasma D-dimer level greater than 4 times the upper limit of normal based on local laboratory criteria or a sepsis-induced coagulopathy score of 4 or greater.
Excluded criteria: [summary of most important criteria]
physician determined need for full-dose anticoagulation or dual antiplatelet therapy
bleeding within the past month,
active gastrointestinal or intracranial cancer,
bronchiectasis or pulmonary cavitation,
hepatic dysfunction with baseline international normalized ratio greater than 1.5,
creatinine clearance (CrCl) less than 15mL/min/1.73m2 ,
platelet count less than 25 000/μL,
history of heparin-induced thrombocytopenia (HIT) within 100 days,
hypersensitivity/intolerance to study drug or components.
Selection bias (biased allocation to interventions) due to inadequate generation of a randomised sequence
Selection bias (biased allocation to interventions) due to inadequate concealment of allocations prior to assignment
No information about the if the allocation
sequence was concealed
No information about the if the allocation
sequence was concealed
No information about the if the allocation
sequence was concealed
No information about the if the allocation
sequence was concealed
No information about the if the allocation
sequence was concealed
No information about the if the allocation
sequence was concealed
No information about the if the allocation
sequence was concealed
No information about the if the allocation
sequence was concealed
No information about the if the allocation
sequence was concealed
No information about the if the allocation
sequence was concealed
Performance bias due to knowledge of the allocated interventions by participants and personnel during the study
No information about blinding
No infomation about blinding
No info about blinding
No info about blinding
No info about blinding
No info about blinding
No information
No info
No Info
No info
Detection bias due to knowledge of the allocated interventions by outcome assessors
No information about blinding
No information about blinding
No info about blinding
No info about blinding
No infor about blinding
No info about blinding
No information
No info
No info
No info
Attrition bias due to amount, nature or handling of incomplete outcome data
Reporting bias due to selective outcome reporting
Bias due to problems not covered elsewhere in the table
No protocol